Monday, January 27, 2020

Effect of Selective Serotonin Reuptake Inhibitors (SSRIs)

Effect of Selective Serotonin Reuptake Inhibitors (SSRIs) Lynnette Chan Do Selective Serotonin Reuptake Inhibitors (SSRIs) Negatively Affect Memory? Selective serotonin reuptake inhibitors (SSRIs) are the most common antidepressants prescribed to treat moderate to severe depression. SSRIs increase serotonin (5-hydroxytryptamine, 5-HT) levels in the brain by blocking serotonin reuptake. Compared to other antidepressants such as tricyclic antidepressants (TCAs), SSRIs are more selective and have fewer side effects. In addition to affecting emotional moods, SSRIs can also affect food and sex related behaviors, resulting in side effects such as weight gain and reduced sexual drive (Mayo Clinic). However, recent studies indicate that serotonin also plays a â€Å"significant role in learning and memory† (Buhot, Martin, Segu 210). Given serotonin’s lack of specialized function, can SSRIs negatively affect memory function as a side effect? To answer this question, this paper will establish the association between SSRIs and serotonin levels, and then examine the relationship between SSRI use and impaired or improved memory. Since depression has been linked to a shortage of serotonin neurotransmissions, antidepressants should increase 5-HT levels. But in a comprehensive review on the serotonergic and noradrenergic systems of the hippocampus, R. Mongeau, P. Blier, and C. de Montigny found that successful SSRI treatments show both an increase and decrease of 5-HT neurotransmissions (178). This finding is unusual because SSRIs inhibit 5-HT reuptake to increase 5-HT levels and should not result in decreased 5-HT neurotransmissions. As decreased 5-HT levels do appear in successful treatments utilizing SSRIs, there must be additional factors involved in mood elevation within the serotonergic system. Regardless of the exact mechanism that allow SSRIs to treat depressive symptoms, SSRIs do increase and decrease 5-HT neurotransmissions in the brain. While the exact mechanism of how 5-HT levels affect mood remains unclear, SSRI use and changes in 5-HT levels have been linked to memory impairment. In a study investigating the role of serotonin in memory impairment, Marie-Christine Buhot, Stephanie Martin, and Louis Segu found that serotonergic activity in the brain affects memory and learning differently depending on the stimulation or inhibition of different 5-HT receptor subtypes. This study found that stimulation of the 5-HT2A/2C or 5-HT4 receptor subtypes, or inhibition of the 5-HT1A or 5-HT3 or 5-HT1B receptor subtypes improved memory and learning in high-cognitive activities (210). 5-HT receptor subtypes are differentiated by their relative distributions in the brain and their cellular locations, differentiations that explain the various effects of 5-HT receptor subtypes. For example, the 5-HT1A receptor subtype is largely concentrated in the hippocampus and interacts with the noradrenergic, dopaminergic, and GABAergic syste ms (Buhot, Martin, Segu 214). As a result, stimulating 5-HT1A receptors impairs memory. The Buhot study confirms that serotonin affects memory function and is dependent on the stimulation or inhibition of different 5-HT receptor types or subtypes. The Buhot study examined the neurotransmitter mechanisms of serotonin and memory, but it did not examine the effect of specific SSRI antidepressants on memory. In a study on the effect of short-term use of SSRIs on cognitive brain function, Jeroen A. J. Schmitt, Monique J. Kruzinga, and Wim J. Riedel found that the positive and negative effects SSRIs have on memory is caused by interactions with external neurotransmitter systems. The study conducted tests with sertraline and paroxetine, the two â€Å"most potent inhibitors of serotonin reuptake† available at the time of the study (Schmitt, Kruzinga, Riedel 173). They found that paroxetine contributed to long-term memory impairment, an effect attributed to paroxetine’s additional anticholinergic properties. On the other hand, sertraline only slightly improved verbal fluency, an effect attributed to sertraline’s additional dopaminergic effects. Although this study agrees with the Buhot study that additional neurot ransmitter interactions in serotonergic pathways contribute or prevent memory impairment, the Buhot study attributes memory functions to serotonin while the Schmitt study does not. Both the Buhot and Schmitt studies argue that SSRIs influence memory, but the two studies disagree on the mechanism that causes memory improvement and impairment. In a study examining the short-term use of the SSRI citalopram and the SNRI (serotonin-norepinephrine reuptake inhibitor) reboxetine and their effect emotional memory and perception, Catherine J. Harmer, Nicholas C. Shelley, Philip J. Cowen, and Guy M. Goodwin found that both citalopram and reboxetine decreased the memory and perception of negative emotions in comparison to positive emotion. Additionally, citalopram use lowered startle responses to displays of negative emotion. Unlike the Buhot and Schmitt study, this study claims that SSRI’s side effect on emotional memory and perception is actually the mechanism that makes SSRIs effective antidepressants. Perhaps SSRIs help strengthen memories of positive emotions with increased 5-HT concentrations and weaken memories of negative emotions with decreased 5-HT concen trations at different 5-HT receptor subtypes to contribute to mood elevation and regulation. SSRIs have a recognized role in memory and learning. The Buhot study argues that memory can be strengthened or weakened depending on the inhibition or stimulation of different 5-HT receptor subtypes, characterized by location and neurotransmitter pathways. On the other hand, the Schmitt study argues that SSRIs effect on memory is not caused by 5-HT levels, but by the additional effects of other neurotransmitter systems. In contrast, the Harmer study argues that the strengthening and weakening of emotional memory and perception contributes to the antidepressant properties of SSRIs. In conclusion, SSRIs can both impair and improve memory, depending on the SSRI type and their interactions with 5-HT receptor subtypes and other neurotransmitter pathways. SSRIs have been confirmed to affect memory and cognitive function, but further research is required to determine the exact mechanism of how different SSRIs affect neurotransmitters and mood. Research can explore the degree of memory impairment caused by SSRIs, and examine the neurotransmitter systems that interact most with the serotonergic system to better define neurotransmitter function. Future research can also focus on developing new antidepressants by exploring the neurotransmission systems that interact with SSRIs. Hopefully, a more comprehensive understanding of the mechanisms of memory and the role of neurotransmitters can also provide better insight on neurodegenerative disorders that affect memory, such as Alzheimers disease. Works Cited Buhot, Marie-Christine, Stà ©phanie Martin, and Louis Segu. Role of Serotonin in Memory Impairment. Annals of Medicine 32.3 (2000): 210-21. Informa Healthcare. Web. 26 Feb. 2015. http://informahealthcare.com/doi/abs/10.3109/07853890008998828>. Harmer, Catherine J., Nicholas C. Shelley, Philip J. Cowen, and Guy M. Goodwin. Increased Positive Versus Negative Affective Perception and Memory in Healthy Volunteers Following Selective Serotonin and Norepinephrine Reuptake Inhibition. American Journal of Psychiatry 161.7 (2004): 1256-263. American Journal of Psychiatry. Web. 26 Feb. 2015. http://ajp.psychiatryonline.org/doi/abs/10.1176/appi.ajp.161.7.1256>. Mayo Clinic. Depression (major Depressive Disorder). Selective Serotonin Reuptake Inhibitors (SSRIs). January 1, 2015. Accessed March 18, 2015. http://www.mayoclinic.org/diseases-conditions/depression/in-depth/ssris/art-20044825. Mongeau, R., P. Blier, and C. De Montigny. The Serotonergic and Noradrenergic Systems of the Hippocampus: Their Interactions and the Effects of Antidepressant Treatments. Brain Research Reviews 23.3 (1997): 145-95. Science Direct. Web. 26 Feb. 2015. http://www.sciencedirect.com/science/article/pii/S0165017396000173>. Schmitt, Jeroen A. J., Monique J. Kruizinga, and Wim J. Riedel. Non-serotonergic Pharmacological Profiles and Associated Cognitive Effects of Serotonin Reuptake Inhibitors. Journal of Psychopharmacology 15.3 (2001): 173-79. Sage Journals. Web. 26 Feb. 2015. http://jop.sagepub.com/content/15/3/173.short>.

Saturday, January 18, 2020

Organic food sector

This document is an information report providing a micro and macro environmental analysis of the organic industry. It gives specific attention to the European and German market and to the retail industry in particular. A brief introduction, also focusing on the reasons and criteria for the selection of such sector, will be followed by an assessment of the aspects at the micro and macro level that affect the players operating in it. To facilitate the analysis I will pretend that the writer of the following report is a manager operating in the broader food industry.Since we operate in the food retail industry, both nationally (Germany) and on the European level, I suggest, as sales director of this company, to consider entering the organic branch, since it has been growing steadily in the last 2 decades. Organic farming can be regarded as method of production that gives particular attention to environmental protection and animal welfare, thus avoiding the adoption of synthetic chemical means and the production of genetically modified organisms. The industry is highly regulated, requiring producers to acquire special certification to sell goods as organic within given borders.The market has been growing steadily, as suggested above, and is still doing so despite the economic and financial crisis; it grew globally by more than 25 per cent since the start of the global crisis between 2008 and 2011. According to the latest data (Fill and ‘FOAM, 2013), 37. Million hectares of agricultural land are nowadays organic (they were 11 million only in 1999) and 1. 8 million producers world-wide are reported (from 252 thousand in 2000). The global sales have also seen a dramatic increase, climbing by almost 200% in the last 10 years.Although this industry accounts only for 1-2% of the total food production globally, almost 10% of the total food sales share is covered by it. Fig 1 . Organic agricultural land by region, 1999-2010 Despite the number of producers and retaile rs, as I will elucidate later in this report, has been increasing year after year in order to cover the high demand for this kind of rodents (mostly driven by concerns about private health on one hand and the global environment on the other), I believe there are still good opportunities for ambitious firms to enter – at any point of the supply chain – this relatively new and steadily expanding market. . Macro environmental analysis The environment where firms operate includes several forces that affect their activity, from the acquisition of resources, through the process of transformation of such input, and finally to the creation of an output. The more external forces (general or contextual, such as political, cultural, social and legal) are the ones influencing the rim in a more general way, as opposed to the operational ones, which affect the business on a daily basis (Ian and Christ, 2006).In this part I will refer to the external range of influences and observe h ow these can have an impact on the organic industry. As said, the focus will be on the European market and on Germany, which represents the biggest player in the E area and the second largest globally. Selection of factors To carry out this task I have asked my team of analysts to perform a Pestle analysis, which takes into account political, economic, socio-cultural, technological, legal and environmental aspects.It is usually performed by almost every major and minor organization in order to get an overview of the whole scenario of a particular industry or branches of it. Of course the elements considered vary in importance based on the industry and the goods involved. In the organic sector's case, the socio-cultural, political and legal aspects are particularly crucial and the report will give a particular attention to these; in addition, other factors not (directly) included in Pestle but that it is important to mention when analyzing this particular industry, are the demographi c and regulatory ones.Environmental issues also represent a major concern. 2. 1 Specific macro-factor analysis 2. 1. 1 Political factors These basically represent to what extent the government (local, national or supra- national) intervenes in a particular industry. Demand for bio products and the growing popularity of organic farming within Europe has fostered the development and implementation – through the European Commission, The EX. Council and the EX. Parliament – of official rules, programmed and plans.This level of action is closely related to the regulatory one, which will be more thoroughly addressed in the section following this one. The most relevant document to mention in this part is the â€Å"European action plan for organic food and farming†, which comprises 21 initiatives in order to develop the market and get better standards by increasing transparency, reliability, efficacy and consumers' trust. Also at the national level many governments have been providing their plans and policies in order to support the growth and efficiency of the organic industry.In Germany, for instance, the range of governmental assistance in the last decade has increased significantly both through the Federal Government and the Leander; the measures are directed both to organic agriculture and to the whole supply chain (Nibbler and Kenneth, 2007). Environmental objectives, as well as the opportunity for rural development, are the main goals of the government's financial, legal and regulatory support for operators dealing in this industry. 2. 1. 2 Legal and regulatory factors The political intervention in the industry is, as discussed, very present and fundamental for its growth.Although it might benefit the overall sector, the high level of laws and regulations represent nonetheless a potential barrier for new entrants. In 2009 the EX. introduced new regulations regarding the production, control and babbling of organic goods. These put an ever bi gger attention to environmental, animal and consumer protection and health. For instance, food can be sold as organic only if 95% of its ingredients derive from organic agriculture and processing. Closed cycles (using internal resources) are favored to open cycles; external resources should be limited to natural or naturally obtained materials.Only in exceptional cases, thoroughly evaluated by the European Commission, chemical synthetic resources may be allowed if other suitable alternatives are not available. 2. 1. 3 Economic factors Europe has, according to the Research Institute of Organic Agriculture, 25% of the world's organic farmland, but it represents almost half of the global revenue within organic industry (the American market is still the world's largest). Sales of organic products were approximately 21. 5 billion Euros in 2011 (Fill, 2013).The largest market for organic products is Germany, with almost 7 billion Euros (Nielsen and Braun, 2013), followed by the I-J (3 bil lion Euros), France and Italy (both 2 billion Euros). Fig 2. Sales growth of German market in 2012 The German market grew by 6% in 2012 up to 7. 04 billion Euros, showing a stable Roth and representing 3. 9% of the entire food market; the increase in the previous year had been even higher (9%), influenced by several food scandals that drove more and more consumers from conventional food to bio products.Fig 3. Sales growth from 2000 to 2012 Fig 4. Organic food sales in Germany (2012) 2. 1. 4 Socio-cultural factors (and demographic ones) A growing number of people are nowadays more informed, health- and environment- conscious than ever; they are thus willing to spend more on healthy natural foods, since there is widespread public belief that organic food is much safer, more atrocious, and environmental friendlier than conventional food.In any case it is important to note that â€Å"regardless of whether any measurable health benefits exist from consumption of organic produce, the pub lic perception of health gains associated with organic produce is undoubtedly influenced by statements that are not (yet) able to be supported by scientific evidence. † (Givens, 2008).Demography also plays a very important role in an increasingly aging Europe; in Germany (one of the countries with the lowest birth rate), the typical heavy consumer of this kind of rodents is in his mid ass (thus belonging to the generation of the forerunners of the ecological movement in this country) and with a good income level. Young consumers, such as students and entry level workers, tend to opt for more affordable options. The market is slowly opening to 30+ customers, mostly young professionals fond of a healthy and dynamic life-style. . Micro environmental analysis This section of the report will mainly focus on Porter's â€Å"5 forces analysis†, concentrating the analysis on those factors that can more directly influence the daily activities of a firm operating in the organic in dustry, affecting its ability to satisfy its customers and make a profit. As the producers' scenario is particularly fragmented, the study will give particular attention to the German retail industry and often assume the perspective of the five largest specialist retail chains operating in it.Three forces relate to ‘horizontal' competition, such as the threat of substitute products or services, the threat of established rivals, and the threat of new entrants; the two remaining forces represent ‘vertical' competition: the bargaining power of suppliers and the one of customers. . 1 Threat of established rivals (intensity of competitive rivalry) In Germany organic products are sold as follows: 35% in traditional supermarkets (around 40. 00 shops) 23% in specialist shops (around 2000 shops; there are 17 organic supermarket chains, the 5 biggest are Lunar, Vital, Den's Bio, Basic and Redford). 19% in discounts supermarkets (more than 10. 000 shops) Fig 5. Number of specialize d organic outlets in Germany (2008) It is therefore clear that, despite being this sector quite young, the number of actors operating in it is very high; this great level of rivalry determines a high threat to profits.It is furthermore important to note that these operators vary consistently in cost structures and have different levels of exit barriers; bigger, traditional retailers/ wholesalers (such as Metro, Rowe and Deeds) have an advantage in terms of economies of scale, although they will have to face stronger exit barriers, considering the amount of their investments. According to recent research (Bifocal, 2010), the further development of the specialized organic market sector will see a decrease in terms of market share in favor of traditional supermarkets; nevertheless, the overall turnover will increase.This is mainly due to the fact that specialized retailers can provide a wider range of products, a more regular supply, competent staff and the availability of non-foods it ems as well. 3. 2 Threat of new entrants The highest threat is represented by traditional supermarkets with re-branding strategies towards the organic sector, since completely new entrants would face and be discouraged by very strong entry barriers in terms of capital requirements, economies of scale, amount of regulations, experience curve and access to key inputs. The resulting threat to profits can therefore be regarded as medium. 3.Threat of substitute products There are not many direct substitutes for organic food and as long as a large portion of the public will be convinced that it is safer, healthier, more nutritious and even tastier than conventional one, its higher prices will be Justified and the branch will maintain if not increase the market share. Nonetheless, local farmers' markets provide a good alternative for individuals fond of food with no pesticides and with a low environmental impact; even so, their prices are not rarely higher than the ones offered in supermar kets (even if specialized) and their presence on the territory is ere scarce.There are some products and services that could be listed as indirect substitutes, since they also help satisfy the desire of a healthier and CEO-friendly life- style. Fitness centers, wellness programs and sustainable tourism are Just some of these. Despite this, it is important to stress the fact that nutrition is usually regarded as the most crucial factor when it comes to choices taken by consumers in order to improve their personal health and reduce the negative effects on the environment.The resulting level of threat to profits from substitute products can again be regarded as medium. 3. Bargaining power of buyers Consumers' power in this industry is mostly influenced by the following factors: Price sensitivity Buyers are ready to spend more than on conventional food provided that this is justified by higher levels of quality, freshness, taste and the certainty (provided by certificates and labels) th at the production and packaging of goods respect specific standards and norms.Despite this general observation, discount supermarkets have been lately offering similar products to the one displayed in specialized chains for sensibly lower prices, alerting customers that a similar quality can be obtained also or half of the usual price. Price sensitivity is therefore increasing. Information availability This kind of consumer is usually extremely educated and informed and consequently expects a high level of transparency, as well as being well aware of the different alternatives available in order to satisfy his demand.Degree of dependency upon existing channels of distribution Buyers have been increasingly attracted by the offers displayed in the Internet through more or less specialized organic e-shops. This could represent a potential threat (as well as an opportunity for further investment), although most consumers till rely on traditional channels, offering, among other services, the availability of competent and specialized staff.Availability of substitute products See above The resulting level of threat from this force can be regarded as medium to high. 3. 5 Bargaining power of suppliers Contrarily to the US market, where suppliers are extremely concentrated (with local farmers often signing contracts with big corporations) and represent the real dominant power in the organic industry, in Europe they are still very fragmented.They do not represent a big threat for the retail industry. It is furthermore not likely for suppliers to tend towards forward vertical integration. The resulting level of threat from this force can be regarded as low to medium The above mentioned observations can be summarized in the following table, which underlines the micro environmental factors within the organic (retail) industry and their level of threat. Fig 6. Porter's five forces summary 4.Further relevant specific market issues: recent developments in the target market Res earchers Budded and Ham (2011) observe that the traditional parameters necessary to define the usual buyer of organic products (e. . Level of income and education, age, as indicated above), have almost completely lost their previous importance in the last few years; the authors have thus come to the conclusion that marketing campaigns should concentrate on health-orientated specific needs, underlining the naturalness of goods and their lacking of chemically produced ingredients.

Friday, January 10, 2020

Jane Cazneau Essay

Hudson posits a Native American grandmother, although there is no solid evidence of this. Her first marriage apparently dissolved, but there is no divorce record. She may or may not have had an affair with Aaron Burr, an early mentor. Hudson’s most significant claim is that Jane Storm is the journalist who coined the phrase â€Å"manifest destiny† (pp. 60-62). Hudson argues that later historians have simply assumed that John O’Sullivan wrote the Democratic Review’s many unsigned editorials. But Hudson’s computer analysis (Appendix B) of O’Sullivan’s and Storm’s signed works shows that the grammatical errors in the famous editorial that first contained the phrase exhibit a much closer correlation with those commonly made by Storm than with those made by O’Sullivan. What is certain is that she migrated to pre-revolutionary Texas and speculated in land grants and immigration schemes. Writing under the pen name â€Å"Montgomery† (later, â€Å"Cora Montgomery†), Storm became a regular correspondent of Moses Y. Beach’s New York Sun. When war broke out, Storm accompanied Beach and his daughter on a covert peace mission to Mexico in late 1846. The Beach mission has long been clouded with uncertainty about its purposes and accomplishments, and so Storm’s role in it is similarly in doubt. Nonetheless, she was clearly an important element, as neither of the Beaches knew Spanish and President James K. Polk had a private interview with her after her return. After the war, Storm continued to favor U. S. xpansion into Latin America and the Caribbean, especially through annexation. Although Hudson maintains that Storm was not a strong proponent of â€Å"All Mexico† during the U. S. -Mexican War, some have credited her with leading the movement. She had contact with Cuban, Mexican, and Nicaraguan filibustering groups. She married diplomat Williams L. Cazneau in 1849 after a long acquaintance but still worked as a journalist for numerous publications, wrote about her travels, and r emained active in Democratic Party politics. She secured a diplomatic mission to the Dominican Republic for her husband and worked with him to gain U. S. access to Samana Bay. Jane Storm Cazneau died in a shipwreck during a storm at sea in 1878. Many questions about her activities and the extent of her influence remain unanswered. Barring the emergence of new documentary collections, Hudson’s biography is the most complete picture of her life we are likely to have. As such it is a useful addition to the literature on nineteenth-century U. S. expansionism.

Thursday, January 2, 2020

Workplace Violence Essay - 2488 Words

Workplace Violence In January 1997, a man drove into the parking lot of a major company in Baltimore County, pulled out a gun, and aimed it at his girlfriend who was sitting in her car and killed her. The man shot himself. Several days after that, another man in another part of the county, in attempt to commit suicide, drove his vehicle the wall of a business and injured an employee who was sitting at his desk. (National, 1996) There is a general perception that violence is growing in our society. Almost everyday we can turn on the news or read the newspaper and we hear stories about horrific workplace murders and assaults. Not only is the workplace violence increasing in those workplaces where violence is expected, such as†¦show more content†¦(Bowie, 1989) Clearly, something must be done. Employees not only deserve a safe work environment several states mandate it. Labor attorneys recognize that employers may be exposing their corporations to potentially costly litigation if there is no Workplace Violence Prevention Program and executives are being made aware of the enormous costs associated with incidents involving occupational violence. (California, 1995) Many questions deserve closer examination: What is work-place violence and who perpetrates it? What are the causes? Why the increase in workplace related violence? How does an incident involving occupational violence affect a business economically? And what can be done to avoid violence in the workplace? What is workplace violence? The workplace is any place a worker performs a job, such as an office, hospital, parking lot, private residence or public building. Violence is defined as any act of aggression that causes physical or emotional harm, such as physical assault, rape, verbal abuse, threats and even sexual harassment. Type of assault would include pinching, biting, hitting, grabbing, kicking, or being struck by a weapon. Almost any object can be used as a weapon. The causes of workplace violence are complex, however a few major factors are: †¢ Violent Society- We lives in a violent society. More guns are on the street and more people are willing to address their problem through violence.Show MoreRelatedWorkplace Violence And The Workplace2844 Words   |  12 PagesWorkplace Violence statics across the United States of America have been on a steady rise each year since the early 1990’s. Reports have consistently shown in recent years that than an average of 500 homicides and 1.5 million assaults occur each year in America, in the workplace. With those types of statics on the rise in America it’s clear that a Workplace Violence Program is essential to the health, welfare, safety, and security of our employees in the workplace. 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UNLV Theses/Dissertations/Professional Papers/Capstones. Paper 522. http://digitalscholarship.unlv.edu/thesesdissertations/522 This Capstone is brought to you for free and open access by Digital Scholarship@UNLV. It has been accepted for inclusion in UNLV Theses/Read MoreWorkplace Violence And Its Effects On The Workplace834 Words   |  4 Pagesspecialists, medical attendants and assistants who manage psychiatric patients; individuals from crisis restorative reaction groups; and doctor s facility workers working in confirmations, crisis rooms, and emergency or intense consideration unit. This is violence committed by an aggressor who either gets administrations from or is under the custodial supervision of the influenced work environment or the casualty. 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Workplace Violence accounted for more than two (2) million violent Crimes annually from 1992-1997 (Kaufer 1-2). In this research paper I will provide an overview of workplace violenceRead MoreEssay on Workplace Violence620 Words   |  3 PagesWorkplace Violence Workplace violence can be defined as any action that can threaten the safety of an employee, impact the employees psychological or physical well being, or cause damage to a companys property. Workplace violence is not often talked about, but it does kill people. In the last decade it has become one of the leading causes of deaths in the workplace. The University